The Solution for Catheter Infections: Prevention and Treatment
Geistlich TauroSept®: Taurolidine 2% solution to prevent the risk of catheter infection and adjuvant treatment in case of infected catheters.Register and download the brochure
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Catheter-related bloodstream infections (CRBSI)
CRBSIs (catheter-related bloodstream infections) continue to be associated with considerable morbidity and mortality and cause high treatment costs. Optimal avoidance of infection and infection control are an absolute necessity when dealing with central vascular access devices (CVADs). Nevertheless, the incidence of CRBSI in Europe is 2 – 4.6 per 1000 catheter days despite the most varied preventive measures and the mortality of CRBSI is still between 5 and 25 %. (14, 15, 21) The risk of CRBSI increases steadily depending on the duration of catheterisation.
The benefits of Geistlich TauroSept®
The best prevention against the development of CRBSIs is observation of strict hygiene guidelines when inserting and manipulating a CVAD. In addition, the instillation of antimicrobial solutions like Geistlich TauroSept® into the device lumen (antimicrobial lock) has been shown to be clinically effective. (1, 8, 10, 17, 20)
Geistlich TauroSept® is intended for instillation in CVADs between treatments in order to prevent bacterial and fungal growth leading to microbial infection in the CVAD lumen as well as to maintain device patency and avoid staphylocoagulase-mediated coagulation.
Prevention of catheter infections
- Broad bactericidal and fungicidal spectrum (22)
- Effective against antibiotic-resistant bacteria (23)
- No development of bacterial resistance known (16)
Treatment of infected catheters
- Resolves the catheter biofilm (12,24)
- Detoxifies endo- and exotoxins (2)
Prevention of catheter thrombosis
- Inhibits blood coagulation factors (25)
- Prevents surface activiation of platelets (19)
- Inhibits staphylocoagulase activity (26)
- Can be flushed (7)
- Rapidly metabolized to Taurine, H₂O and CO₂ (27)
European nephrology guidelines ERBP (European Renal Best Practice), 2010
"Preventive use of antimicrobial lock is desirable to reduce the rate of CRBSI.” (28)
ESPEN guidelines on chronic intestinal failure in adults, 2016
“We suggest that catheter locking with taurolidine may be used to prevent central venous catheter related infections.” (29)
GAVeCeLT consensus. J Vasc Access 2016
“ The drugs most likely to be used as antibacterial locks are taurolidine and citrate, which have optimal characteristics in terms of safety, efficacy and cost effectiveness.” (30)
Presentation and package sizes
Each original pack contains 5 glass vials containing 6 ml or 10 ml of Geistlich TauroSept®. The product is sterile. Opened Geistlich TauroSept® vials can be stored for 48 hours and multiple withdrawal is possible. The content of a vial is for a single patient only and must be used within 48 hours after the first puncture.
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4 Bouza, E., R. San Juan, et al. (2004). “A European perspective on intravascular catheter-related infections: report on the microbiology workload, aetiology and antimicrobial susceptibility (ESGNI-005 Study).” Clin Microbiol Infect 10(9): 838–42.
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8 Jonkers, C., K. I. Looman, et al. (2012). “Incidence of central venous catheter related bloodstream infections in adults and children on home parenteral nutrition: heparin versus taurolidine catheter lock “ Clinical Nutrition Supplements 7(1): 203–204.
9 Jurewitsch, B., T. Lee, et al. (1998). “Taurolidine 2 % as an antimicrobial lock solution for prevention of recurrent catheter-related bloodstream infections.” JPEN J Parenter Enteral Nutr 22(4): 242–4.
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11 Knight, B. I., G. G. Skellern, et al. (1981). “The characterisation and quantitation by high-performance liquid chromatography of the metabolites of taurolin.” Br J Clin Pharmacol 12 (3):439–40.
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17 Olthof, E. D., M. W. Versleijen, et al. (2014). “Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions.” PLoS One 9 (11): e111216.
18 Olthof, E. D., R. Nijland, et al. (2015). “Microbiocidal effects of various taurolidine containing catheter lock solutions.” Clin Nutr 34 (2): 309–14.
19 Reinmuller, J. (1999). “[The influence of taurolidine on physiological and pathological blood coagulation and implications for its use].” Zentralbl Chir 124 Suppl 4: 13–8.
20 Sherertz, R. J., M. S. Boger, et al. (2006). “Comparative in vitro efficacies of various catheter lock solutions.” Antimicrob Agents Chemother 50(5): 1865–8.
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29 Pironi L et al. ESPEN guidelines on chronic intestinal failure in adults. Clin Nutr. 2016. 35 (2):247–307.
30 Pittiruti M et al. J Vasc Access. 2016. 17 (6):453–464.